Wednesday, August 12, 2009

The Mechanism Of Diazepam's Action

GABA is one of these receptors which releases certain chemicals and controls the excitability of the brain. These chemical levels, when balanced, keep the excitability of the brain to normal level. Any positive or negative change in their balances disturbs the way our brain works and hence the body experience anxiety disorders. Diazepam brings the excitability of brain neurons to normal level by working on GABA. GABA has subunits and inhibitory channels. GABAA receptor is one of these inhibitory channels, which is activated to slow down the neuronal action. Diazepam works on the Cerebral cortex and performs action on the limbic system, the body parts controlled by thalamus and hypothalamus. Diazepam also relaxes the muscles by inhibiting the polysynaptic trails in the spinal cord. Benzodiazepine containing diazepam does not affect the GABA levels but inhibits the neuron activity by controlling the negative chloride ions. The mechanism of Diazepam’s action is thus classified as inhibitory.